奇怪，国内居然是独家申报，独家获得批件，是技术上很难吗？还是有专利问题？
盼高手指点！！感激
有人报啊!就是效果嘛??
它挺早上市的，在法国、意大利及西班牙等，好像韩国和台湾也有卖。下面是临床研究，好像结果还不错。八几年，应该没专利吧！制备没啥难得，结构也不复杂，就不知现在国外还用这药吗！！！！
A double blind vs placebo study was carried out to study the effect of letosteine on the symptoms and clinical course of paediatric patients suffering from acute febrile bronchitis. Forty children were recruited for the research: 20 were treated with letosteine in a dose of 25 mg x 3 g/die and 20 with placebo; treatment lasted 10 days. The following parameters were assessed during the trial: body temperature, cough, thoracic objectivity, respiratory function indices. The results of the study show that in the letosteine treated group there is a statistically significant decrease in fever, a favourable evolution of thoracic objectivity and an improvement in certain respiratory function parameters (MEF 75, PEF). It is concluded that treatment with letosteine leads to a significant increase in the rate of regression of thoracic symptomatology and a faster, more substantial reduction in fever in children suffering from acute bronchitis. This is probably the result of drug action on mucus viscosity, restoring optimal mucociliary clearance, and through action fostering the penetration of antibacterial substances into the mucus.
国外现在都停用了。。。
盼高手指点！！感激
有人报啊!就是效果嘛??
它挺早上市的，在法国、意大利及西班牙等，好像韩国和台湾也有卖。下面是临床研究，好像结果还不错。八几年，应该没专利吧！制备没啥难得，结构也不复杂，就不知现在国外还用这药吗！！！！
A double blind vs placebo study was carried out to study the effect of letosteine on the symptoms and clinical course of paediatric patients suffering from acute febrile bronchitis. Forty children were recruited for the research: 20 were treated with letosteine in a dose of 25 mg x 3 g/die and 20 with placebo; treatment lasted 10 days. The following parameters were assessed during the trial: body temperature, cough, thoracic objectivity, respiratory function indices. The results of the study show that in the letosteine treated group there is a statistically significant decrease in fever, a favourable evolution of thoracic objectivity and an improvement in certain respiratory function parameters (MEF 75, PEF). It is concluded that treatment with letosteine leads to a significant increase in the rate of regression of thoracic symptomatology and a faster, more substantial reduction in fever in children suffering from acute bronchitis. This is probably the result of drug action on mucus viscosity, restoring optimal mucociliary clearance, and through action fostering the penetration of antibacterial substances into the mucus.
国外现在都停用了。。。