各位大虾们，谁能告诉我在哪里能查到索他洛尔的LD50。我在做一个新药，很急啊！
请注意发帖格式！
主题词要加黑括号------【求助】
已经代为改正，并记录为A，请以后注意（直接复制粘贴即可）
http://www.dxy.cn/bbs/post/view?bid=22&id=2130868&sty=1&tpg=1&ppg=1&age=0#2130868
默克索引第十三版
Sotalol
Derivative Type: Hydrochloride
CAS Registry Number: 959-24-0
Manufacturers' Codes: MJ-1999
Trademarks: Beta-Cardone (Evans); Betapace (Berlex); Darob (Knoll); Sotacor (Bristol-Myers Squibb); Sotalex (Bristol-Myers Squibb)
Molecular Formula: C12H20N2O3S.HCl
Molecular Weight: 308.83.
Percent Composition: C 46.67%, H 6.85%, N 9.07%, O 15.54%, S 10.38%, Cl 11.48%
Properties: White crystalline solid, mp 206.5-207?(dec), also reported as mp 218-219?(Singh). Freely sol in water; slightly sol in chloroform. Partition coefficient (water/n-octanol): 0.24; (octan-1-ol/pH 7.4 phosphate buffer) at 37? 0.09. LD50 in male mice, rats (mg/kg): 2600, 3450 orally; 670, 680 i.p.; LD50 orally in rabbits: 1000 mg/kg; LD50 i.p. in dogs: 330 mg/kg (Lish).
Melting point: mp 206.5-207?(dec); mp 218-219?(Singh)
Log P: Partition coefficient (water/n-octanol): 0.24; (octan-1-ol/pH 7.4 phosphate buffer) at 37? 0.09
Toxicity data: LD50 in male mice, rats (mg/kg): 2600, 3450 orally; 670, 680 i.p.; LD50 orally in rabbits: 1000 mg/kg; LD50 i.p. in dogs: 330 mg/kg (Lish)
Therap-Cat: Antianginal; antiarrhythmic (class II + III); antihypertensive.
多谢了！
http://www.drugs.com/pro/sotalol-injection.html
请注意发帖格式！
主题词要加黑括号------【求助】
已经代为改正，并记录为A，请以后注意（直接复制粘贴即可）
http://www.dxy.cn/bbs/post/view?bid=22&id=2130868&sty=1&tpg=1&ppg=1&age=0#2130868
默克索引第十三版
Sotalol
Derivative Type: Hydrochloride
CAS Registry Number: 959-24-0
Manufacturers' Codes: MJ-1999
Trademarks: Beta-Cardone (Evans); Betapace (Berlex); Darob (Knoll); Sotacor (Bristol-Myers Squibb); Sotalex (Bristol-Myers Squibb)
Molecular Formula: C12H20N2O3S.HCl
Molecular Weight: 308.83.
Percent Composition: C 46.67%, H 6.85%, N 9.07%, O 15.54%, S 10.38%, Cl 11.48%
Properties: White crystalline solid, mp 206.5-207?(dec), also reported as mp 218-219?(Singh). Freely sol in water; slightly sol in chloroform. Partition coefficient (water/n-octanol): 0.24; (octan-1-ol/pH 7.4 phosphate buffer) at 37? 0.09. LD50 in male mice, rats (mg/kg): 2600, 3450 orally; 670, 680 i.p.; LD50 orally in rabbits: 1000 mg/kg; LD50 i.p. in dogs: 330 mg/kg (Lish).
Melting point: mp 206.5-207?(dec); mp 218-219?(Singh)
Log P: Partition coefficient (water/n-octanol): 0.24; (octan-1-ol/pH 7.4 phosphate buffer) at 37? 0.09
Toxicity data: LD50 in male mice, rats (mg/kg): 2600, 3450 orally; 670, 680 i.p.; LD50 orally in rabbits: 1000 mg/kg; LD50 i.p. in dogs: 330 mg/kg (Lish)
Therap-Cat: Antianginal; antiarrhythmic (class II + III); antihypertensive.
多谢了！
http://www.drugs.com/pro/sotalol-injection.html