1． Cdk2抑制剂的药物动力学模型
Bioluminescent imaging of Cdk2 inhibition in vivo
Nature Medicine 10(6), 643-648, Jun 2004
2． 喜树碱类抗癌新药托泊替康(topotecan)的临床前研究
Schedule-dependent inhibition of hypoxia-inducible factor –1α protein accumulation ,angiogenesis ,and tumer growth by topotecan in U251 HRE glioblastoma xenografts
Cancer Research 64, 6845-6848, Oct 1, 2004
3． Sugen公司(已经被Pfizer收购)抗乳腺癌药物SU11248的临床前药效评价
In Vivo Antitumer Activity of SU11248，a Novel Tyrosine Kinase Inhibitor Targeting Vascular Endothelial Growth Factor and Platelet-derived Growth Factor Receptors: Determination of a Pharmacokinetic/Pharmacodynamic Relationship
Clinical Cancer Research 9, 327-337, Jan 2003
4． 抑制低氧诱导因子通路的小分子药物黑毛霉素（chetomin）抗癌疗效评价
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
Cancer cell , 6 ,33-43 ,Jul ,2004
5． 酪氨酸激酶抑制剂PKC412治疗急性淋巴细胞白血病的疗效观察
Inbibition of FLT3 in MLL:Validation of a therapeutic target identified by gene expression based classification
Cancer cell , 3,173-183 ,Feb ,2003
6． AMD 3100 治疗原发性脑肿瘤的药效评价
A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors.
PNAS 100(23), 13513-13518, Nov 11, 2003
7． MAP激酶抑制剂CI 1040治疗黑色素瘤肺转移的疗效观察
Treatment of Metastatic Melanoma with an Orally Available Inhibitor of the Ras-Raf-MAPK Cascade.
Cancer Research 63, 5669-5673, Sep 15, 2003
8． 细胞毒抗癌药物MLN2704（抗体化疗复合物）治疗成骨细胞前列腺癌转移的疗效观察
A Prostate-Specific Membrane Antigen-Targeted Monoclonal Antibody-Chemotherapeutic Conjugate Designed for the Treatment of Prostate Cancer.
Cancer Research 64, 7995-8001, Nov 1, 2004
9． Epothilone 类似物治疗骨髓瘤的疗效观察
Investigation of antitumor effects of synthetic epothilone analogs in human myeloma models in vitro and in vivo
PNAS 102(30): 10640-10645 , July 26 , 2005
10． 药物代谢
The orphan nuclear receptor HNF4α determines PXR- and CAR-mediated xenobiotic induction of CYP3A4.
Nature Medicine 9(2), 220-224, Feb 2003
11． 药物抗药性逆转筛选模型
Imaging reversal of multidrug resistanse in living mice with bioluminescence : MDR1 P-glycoprotein transports coelenterazine
PNAS 101(6),1702-1707 ,Feb 10 ,2004
12． 药物对蛋白质相互作用的影响
Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals
PNAS 101(33), 12288-12293, Aug 17 , 2004
13． 治疗传染性心内膜炎的抗生素筛选模型
Real-time in vivo bioluminescent imaging for evaluating the efficacy of antibiotics in a rat Staphyococcus aureus endocarditis model
Antimicrobial Agent and Chemotherapy 49(1): 380–387，Jan , 2005
14． 抗炎症化合物药物筛选模型
An Inducible Nitric Oxide Synthase-Luciferase Reporter System for In Vivo Testing of Anti-inflammatory Compounds in Transgenic Mice.
The Journal of Immunology, 2003, 170: 6307–631
15． 药物毒理评价模型
In vivo bioluminescent monitoring of chemical toxicity using heme oxygenase-luciferase transgenic mice
Toxicology and Applied Pharmacology 200(3):219-28 ， Nov 1 ，2004
16． 关于药物研究动物模型的一篇综述
Reporter mice and drug discovery and development
Nature Reviews Drug Discovery Vol. 4, 249-255, March 2005