查了很多资料，我都没有发现关于莫西沙星的理化性质，特别是在低温下的性质。有人知道吗？
性状 MP:324-325℃(分解),-256°,(c=0.5,水).
CA登录号 ,盐酸盐
化学文摘号 CA124:p230582n
专利号 EN 240775,EP550903
引自:汪啸洋 主编《世界上市新药》化学工业出版社，2006
Merck 13:
Monograph Number: 6316
Title: Moxifloxacin
CAS Registry Number: 151096-09-2
CAS Name: 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid
Molecular Formula: C21H24FN3O4
Molecular Weight: 401.43.
Percent Composition: C 62.83%, H 6.03%, F 4.73%, N 10.47%, O 15.94%
Literature References: Fluorinated quinolone antibacterial. Prepn: U. Petersen et al., EP 550903 (1993 to Bayer). Antibacterial spectrum in vitro: J. M. Woodcock et al., Antimicrob. Ag. Chemother. 41, 101 (1997). Activity vs Mycobacterium tuberculosis: B. Ji et al., ibid. 42, 2066 (1998). HPLC determn in serum: C. M. Tobin et al., J. Antimicrob. Chemother. 42, 278 (1998). Clinical pharmacokinetics: H. Stass et al., Antimicrob. Ag. Chemother. 42, 2060 (1998).
Properties: mp 203-208?(dec). 23D -193?
Melting point: mp 203-208°
Optical Rotation: 23D -193°
Derivative Type: Hydrochloride
CAS Registry Number: 186826-86-8
Manufacturers' Codes: Bay-12-8039
Trademarks: Actira (Bayer); Avalox (Bayer); Avelox (Bayer); Octegra (Vita); Proflox (Esteve)
Molecular Formula: C21H24FN3O4.HCl
Molecular Weight: 437.90.
Percent Composition: C 57.60%, H 5.75%, F 4.34%, N 9.60%, O 14.61%, Cl 8.10%
Properties: mp 324-325?(dec). 25D -256?(c = 0.5 in water).
Melting point: mp 324-325°
Optical Rotation: 25D -256?(c = 0.5 in water)
Therap-Cat: Antibacterial.
性状 MP:324-325℃(分解),-256°,(c=0.5,水).
CA登录号 ,盐酸盐
化学文摘号 CA124:p230582n
专利号 EN 240775,EP550903
引自:汪啸洋 主编《世界上市新药》化学工业出版社，2006
Merck 13:
Monograph Number: 6316
Title: Moxifloxacin
CAS Registry Number: 151096-09-2
CAS Name: 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid
Molecular Formula: C21H24FN3O4
Molecular Weight: 401.43.
Percent Composition: C 62.83%, H 6.03%, F 4.73%, N 10.47%, O 15.94%
Literature References: Fluorinated quinolone antibacterial. Prepn: U. Petersen et al., EP 550903 (1993 to Bayer). Antibacterial spectrum in vitro: J. M. Woodcock et al., Antimicrob. Ag. Chemother. 41, 101 (1997). Activity vs Mycobacterium tuberculosis: B. Ji et al., ibid. 42, 2066 (1998). HPLC determn in serum: C. M. Tobin et al., J. Antimicrob. Chemother. 42, 278 (1998). Clinical pharmacokinetics: H. Stass et al., Antimicrob. Ag. Chemother. 42, 2060 (1998).
Properties: mp 203-208?(dec). 23D -193?
Melting point: mp 203-208°
Optical Rotation: 23D -193°
Derivative Type: Hydrochloride
CAS Registry Number: 186826-86-8
Manufacturers' Codes: Bay-12-8039
Trademarks: Actira (Bayer); Avalox (Bayer); Avelox (Bayer); Octegra (Vita); Proflox (Esteve)
Molecular Formula: C21H24FN3O4.HCl
Molecular Weight: 437.90.
Percent Composition: C 57.60%, H 5.75%, F 4.34%, N 9.60%, O 14.61%, Cl 8.10%
Properties: mp 324-325?(dec). 25D -256?(c = 0.5 in water).
Melting point: mp 324-325°
Optical Rotation: 25D -256?(c = 0.5 in water)
Therap-Cat: Antibacterial.