小弟需查佐芬普利药代方面的文献，查了n久都没有啊，特求助大侠啊，在此先谢啦！ 我检索了一下,Zofenopril药代动力学的文献有两遍,是英文的,全文需找到附录的杂志,我想大的图书馆应会有此杂志。
一遍是90年的,一遍是99年的。
PHARMACOKINETICS of Zofenopril
In healthy volunteers, zofenopril was extensively and rapidly hydrolysed after oral administration, and average absorption was 93%. Mean residence time was 3.3h, mean absorption time 1.4h and tmax 0.4h. Pharmacokinetic parameters after administration of zofenoprilat (the active metabolite of zofenopril) in healthy volunteers were renal CL 3.1 ml ． min−1 ． kg−1, nonrenal CL 8.3 ml ． min−1 ． kg−1, Vdss 1.3 L/kg, t½ 5.5h and mean residence time 1.9h. Absolute bioavailability was 78% when based on AUC blood values and 65% when based on urinary excretion values. Zofenopril and zofenoprilat were extensively bound to plasma protein, and elimination was both hepatic and renal 1.
Following a single dose of zofenopril 60mg in healthy volunteers, the tmax was 1.19 and 1.36h for zofenopril and zofenoprilat, respectively. The corresponding half-life was 0.9 and 3.57h. Esterases mediated the biotransformation of zofenopril to zofenoprilat 2.
1. Singhvi SM, Foley JE, Willard DA, Morrison RA.Disposition of zofenopril calcium in healthy subjects. Journal of Pharmaceutical Sciences. 79: 970-973, Nov 1990. USA. . Clinical Trials Insight Journal Fulltext.
2. Marzo A, Dal Bo L, Mazzucchelli P, Monti NC, Tettamanti RA, et al.Pharmacokinetics and pharmacodynamics of zofenopril in healthy volunteers. Arzneimittel-Forschung Drug Research. 49: 992-996, Dec 1999. Switzerland. . Clinical Trials Insight Journal Fulltext.
一遍是90年的,一遍是99年的。
PHARMACOKINETICS of Zofenopril
In healthy volunteers, zofenopril was extensively and rapidly hydrolysed after oral administration, and average absorption was 93%. Mean residence time was 3.3h, mean absorption time 1.4h and tmax 0.4h. Pharmacokinetic parameters after administration of zofenoprilat (the active metabolite of zofenopril) in healthy volunteers were renal CL 3.1 ml ． min−1 ． kg−1, nonrenal CL 8.3 ml ． min−1 ． kg−1, Vdss 1.3 L/kg, t½ 5.5h and mean residence time 1.9h. Absolute bioavailability was 78% when based on AUC blood values and 65% when based on urinary excretion values. Zofenopril and zofenoprilat were extensively bound to plasma protein, and elimination was both hepatic and renal 1.
Following a single dose of zofenopril 60mg in healthy volunteers, the tmax was 1.19 and 1.36h for zofenopril and zofenoprilat, respectively. The corresponding half-life was 0.9 and 3.57h. Esterases mediated the biotransformation of zofenopril to zofenoprilat 2.
1. Singhvi SM, Foley JE, Willard DA, Morrison RA.Disposition of zofenopril calcium in healthy subjects. Journal of Pharmaceutical Sciences. 79: 970-973, Nov 1990. USA. . Clinical Trials Insight Journal Fulltext.
2. Marzo A, Dal Bo L, Mazzucchelli P, Monti NC, Tettamanti RA, et al.Pharmacokinetics and pharmacodynamics of zofenopril in healthy volunteers. Arzneimittel-Forschung Drug Research. 49: 992-996, Dec 1999. Switzerland. . Clinical Trials Insight Journal Fulltext.