请问对氨基进行保护时三氟乙酸酐会与酰胺基上的胺发生反应吗?用三氟乙酰基保护的氨基在什么反应条件下去保护?
没有人能回答一下吗?
The trifluoroacetamide group is one of the more useful amides because of the ease in which it may be removed under mildly basic condition. Otherwise, it is stable to acidic condition such as TFA.
cleavage condition:
1. K2CO3 or NaCO3, MeOH, H2O, rt.
2. LiOH.H2O, THF, MeOH, H2O, rt.
reference:
J. Org. Chem. 53, 3108 9 (1988)
J. Chem. Soc., Perkin Trans. 1, 47 (1990)
,很有用。
第一篇参考文献我找到了,第二篇好像给出的信息不够清楚,能说的详细点吗?
The trifluoroacetamide group is one of the more useful amides because of the ease in which it may be removed under mildly basic condition. Otherwise, it is stable to acidic condition such as TFA.
cleavage condition:
1. K2CO3 or NaCO3, MeOH, H2O, rt.
2. LiOH.H2O, THF, MeOH, H2O, rt.
reference:
J. Org. Chem. 53, 3108 9 (1988)
J. Chem. Soc., Perkin Trans. 1, 47 (1990)
还需要什么信息?1990年那一卷第47页,具体的卷、期我也不是很清楚,二次文献就是这么标注的。
找到了,我以为是47卷呢。
还需要什么信息?1990年那一卷第47页,具体的卷、期我也不是很清楚,二次文献就是这么标注的。
没有人能回答一下吗?
The trifluoroacetamide group is one of the more useful amides because of the ease in which it may be removed under mildly basic condition. Otherwise, it is stable to acidic condition such as TFA.
cleavage condition:
1. K2CO3 or NaCO3, MeOH, H2O, rt.
2. LiOH.H2O, THF, MeOH, H2O, rt.
reference:
J. Org. Chem. 53, 3108 9 (1988)
J. Chem. Soc., Perkin Trans. 1, 47 (1990)
,很有用。
第一篇参考文献我找到了,第二篇好像给出的信息不够清楚,能说的详细点吗?
The trifluoroacetamide group is one of the more useful amides because of the ease in which it may be removed under mildly basic condition. Otherwise, it is stable to acidic condition such as TFA.
cleavage condition:
1. K2CO3 or NaCO3, MeOH, H2O, rt.
2. LiOH.H2O, THF, MeOH, H2O, rt.
reference:
J. Org. Chem. 53, 3108 9 (1988)
J. Chem. Soc., Perkin Trans. 1, 47 (1990)
还需要什么信息?1990年那一卷第47页,具体的卷、期我也不是很清楚,二次文献就是这么标注的。
找到了,我以为是47卷呢。
还需要什么信息?1990年那一卷第47页,具体的卷、期我也不是很清楚,二次文献就是这么标注的。