盐酸曲马多的结构国内药典说是反式，国外有的文献说是顺式，到底是顺式还是反式？药典是否出错，请大家来讨论。
cis-,trans-
Z,E
这两种命名方法是否有矛盾之处？
曲马多结构式.doc (126.5k)
羟基是应该比羟苯基优先吗？那应该是顺式才对啊？
05药典中说这是反式。
参考：这上面写的是 cis-
National Library of Medicine - Medical Subject Headings
2006 MeSH
MeSH Descriptor Data
Return to Entry Page
MeSH Heading Tramadol
Tree Number D02.033.480.300.802
Scope Note A narcotic analgesic proposed for severe pain. It may be habituating.
Entry Term K-315
Entry Term Tramadol Hydrochloride
Entry Term Tramal
Allowable Qualifiers AA AD AE AG AI AN BL CF CH CL CS CT DU EC HI IM IP ME PD PK PO RE SD ST TO TU UR
Pharm. Action Analgesics, Opioid
Pharm. Action Narcotics
CAS Type 1 Name Cyclohexanol, 2-((dimethylamino)methyl)-1-(3-methoxyphenyl)-, cis-(+-)-
Registry Number 27203-92-5
Related Number 36282-47-0
Previous Indexing Anisoles (1974)
Previous Indexing Cyclohexanols (1974)
Previous Indexing Dimethylamines (1974)
History Note 91(75); was see under CYCLOHEXANOLS 1975-90
Unique ID D014147
羟基是应该比羟苯基优先吗？那应该是顺式才对啊？
05药典中说这是反式。
羟基是优先的, 羟苯基基团与羟基比,它以碳开头,而羟基以氧开头.故是顺式的.药典有误.
我也这样认为，但是药典写的反式，国内的产品也都写的反式。
请大家都来看看。
赞成huangxishan13的意见.
Tramadol
Systematic (IUPAC) name
rac-(1R,2R)-2-(dimethylaminomethyl)-1-
(3-methoxyphenyl)-cyclohexanol
-------------------
Tramadol hydrochloride
(±)-cis-2-(Dimethylaminomethyl)-1-(3-methoxyphenyl)cyclohexanol hydrochloride
又学了一点，呵呵
又学了一点，呵呵
肯定是顺式啊，药典错了
cis-,trans-
Z,E
这两种命名方法是否有矛盾之处？
曲马多结构式.doc (126.5k)
羟基是应该比羟苯基优先吗？那应该是顺式才对啊？
05药典中说这是反式。
参考：这上面写的是 cis-
National Library of Medicine - Medical Subject Headings
2006 MeSH
MeSH Descriptor Data
Return to Entry Page
MeSH Heading Tramadol
Tree Number D02.033.480.300.802
Scope Note A narcotic analgesic proposed for severe pain. It may be habituating.
Entry Term K-315
Entry Term Tramadol Hydrochloride
Entry Term Tramal
Allowable Qualifiers AA AD AE AG AI AN BL CF CH CL CS CT DU EC HI IM IP ME PD PK PO RE SD ST TO TU UR
Pharm. Action Analgesics, Opioid
Pharm. Action Narcotics
CAS Type 1 Name Cyclohexanol, 2-((dimethylamino)methyl)-1-(3-methoxyphenyl)-, cis-(+-)-
Registry Number 27203-92-5
Related Number 36282-47-0
Previous Indexing Anisoles (1974)
Previous Indexing Cyclohexanols (1974)
Previous Indexing Dimethylamines (1974)
History Note 91(75); was see under CYCLOHEXANOLS 1975-90
Unique ID D014147
羟基是应该比羟苯基优先吗？那应该是顺式才对啊？
05药典中说这是反式。
羟基是优先的, 羟苯基基团与羟基比,它以碳开头,而羟基以氧开头.故是顺式的.药典有误.
我也这样认为，但是药典写的反式，国内的产品也都写的反式。
请大家都来看看。
赞成huangxishan13的意见.
Tramadol
Systematic (IUPAC) name
rac-(1R,2R)-2-(dimethylaminomethyl)-1-
(3-methoxyphenyl)-cyclohexanol
-------------------
Tramadol hydrochloride
(±)-cis-2-(Dimethylaminomethyl)-1-(3-methoxyphenyl)cyclohexanol hydrochloride
又学了一点，呵呵
又学了一点，呵呵
肯定是顺式啊，药典错了