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如何查国外上市药品的临床资料

时间: 2008-09-19 04:42:46 作者: 来源: 字号:
该药品在美国上市,但在FDA的Drugs@FDA中确找不到,是为什么啊,在哪里能找到它的临床资料,大家!
可以在PDR上面查找!
信息应该还是比较全面的!
PDR上也没有
上pubmed上面找下看看

试试 orange book上面有已经批准的药的全部信息


我在 orange book上 的Orange Book Query中也没搜到, 是我找的不对吗?
我的药品名称是羰基铁(英文名iron carbonyl 或者carbonyl iron),
另外在pubmed 上也没找到想要的东东。
ClinicalTrials.gov (美国)
1、关键是要抓住纲领,你所说药品首研公司是谁,大概Merk index 上会有
2、药品在美国上市,不一定是首先上市国家呢
3、临床资料,检索medline最方便不过啦,这需要你的经验与运气,特别是在关键词的选择哦,如:通用名、商品名、首研公司名,另是哪部分临床资料,如I期呢还是II呢或是药代、药效什么的呢?
4、条条大路通罗马,只要你的布尔逻辑运用得当,在什么网上查已经不一样啦。只要你选用几个有互补性的搜索引擎呢。
先用英文名google,得以下网站

有一些生物利用度和毒理方面的资料
由该网址得其商品名Ferronyl,再google商品名,可看到许多有其规格的制剂,随便找一个

由此可得其生产厂家为DOUGLAS LAB,google这个厂家就出来了

自己在它的PRODUCTS里面找,应该不用我多说了,呵呵。
其实80%的东西是可以GOOGLE的到的,就看你有没有耐心和技巧了。
怎么会没有呢?太多了,下边这些够不?:):)

1. Iron carbonyl, a tracer for phagocytosis in scanning electron microscopy. (eng; includes abstract) By Soligo D, Journal Of The Reticuloendothelial Society , 1982 Sep; Vol. 32 (3), pp. 201-7; PMID: 7153987

2. Relative bioavailability of iron in carbonyl iron and complex ferric orthophosphate to rat. (eng; includes abstract) By Kosonen T, International Journal For Vitamin And Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernährungsforschung. Journal International De Vitaminologie Et De Nutrition , 1992; Vol. 62 (1), pp. 60-5; PMID: 1587710

3. Absorption of carbonyl iron. (eng; includes abstract) By Huebers HA, The Journal Of Laboratory And Clinical Medicine , 1986 Nov; Vol. 108 (5), pp. 473-8; PMID: 3772228

4. Chronic feeding of carbonyl-iron and TMH-ferrocene in rats. Comparison of two iron-overload models with different iron absorption. (eng; includes abstract) By Nielsen P, Comparative Biochemistry And Physiology. C, Comparative Pharmacology And Toxicology , 1993 Oct; Vol. 106 (2), pp. 429-36; PMID: 7904915

5. Carbonyl iron therapy for iron deficiency anemia. (eng; includes abstract) By Gordeuk VR, Blood , 1986 Mar; Vol. 67 (3), pp. 745-52; PMID: 3947745

6.Carbonyl-iron supplementation induces hepatocyte nuclear changes in BALB/CJ male mice. (eng; includes abstract) By Pigeon C, Journal Of Hepatology , 1999 May; Vol. 30 (5), pp. 926-34; PMID: 10365822

7.Comparison of magnesium in human lymphocytes and mononuclear blood cells. (eng; includes abstract) By Yang XY, Magnesium , 1989; Vol. 8 (2), pp. 100-5; PMID: 2755211

8.Suppressor cells generated in mice late after thermal injury. (eng; includes abstract) By Suzuki F, The Journal Of Trauma , 1987 Apr; Vol. 27 (4), pp. 379-83; PMID: 2952804

9. Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities. (eng; includes abstract) By Motterlini R, Circulation Research , 2002 Feb 8; Vol. 90 (2), pp. E17-24; PMID: 11834719

10. Interferon-gamma modulates lung macrophage production of PDGF-BB and fibroblast growth. (eng; includes abstract) By Badgett A, Journal Of Lipid Mediators And Cell Signalling , 1996 Jan; Vol. 13 (1), pp. 89-97; PMID: 8821811

11. Carbonyl-iron supplementation induces hepatocyte nuclear changes in BALB/CJ male mice. (eng; includes abstract) By Pigeon C, Journal Of Hepatology , 1999 May; Vol. 30 (5), pp. 926-34; PMID: 10365822

12. Process of carbonyl iron absorption from the rat duodenal mucosa. (eng; includes abstract) By Nakamura T, Acta Pathologica Japonica , 1988 Nov; Vol. 38 (11), pp. 1377-90; PMID: 3223275

13. Low bioavailability of carbonyl iron in man: studies on iron fortification of wheat flour. (eng; includes abstract) By Hallberg L, The American Journal Of Clinical Nutrition , 1986 Jan; Vol. 43 (1), pp. 59-67; PMID: 3942092

14. Carbonyl iron for short-term supplementation in female blood donors. (eng; includes abstract) By Gordeuk VR, Transfusion , 1987 Jan-Feb; Vol. 27 (1), pp. 80-5; PMID: 3810831

15Comparative assessment of the bioavailability, efficacy and safety of a modified-release (MR) carbonyl iron tablet and oral conventional iron preparation in adult Indian patients with nutritional iron deficiency anaemia. (eng; includes abstract) By Adsul BB, Journal Of The Indian Medical Association , 2005 Jun; Vol. 103 (6), pp. 338-42; PMID: 16225161

16. Bioavailability of carbonyl iron: a randomized, double-blind study. (eng; includes abstract) By Devasthali SD, European Journal Of Haematology , 1991 May; Vol. 46 (5), pp. 272-8; PMID: 2044721

17.Acute toxicity of carbonyl iron and sodium iron EDTA compared with ferrous sulfate in young rats. (eng; includes abstract) By Whittaker P, Regulatory Toxicology And Pharmacology: RTP , 2002 Dec; Vol. 36 (3), pp. 280-6; PMID: 12473412

18.High-dose carbonyl iron for iron deficiency anemia: a randomized double-blind trial. (eng; includes abstract) By Gordeuk VR, The American Journal Of Clinical Nutrition , 1987 Dec; Vol. 46 (6), pp. 1029-34; PMID: 3318377

19.Carbonyl-iron supplementation induces hepatocyte nuclear changes in BALB/CJ male mice. (eng; includes abstract) By Pigeon C, Journal Of Hepatology , 1999 May; Vol. 30 (5), pp. 926-34; PMID: 10365822
各位战友:)
看来我得好好学习一下检索,呵呵
可到Pharmaprojects上查一查
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