不知到园子里有没有人做过“去甲泽拉木醛”这个东西，从雷公藤里面得到的，性质如何。
希望有人指点一二，感激不尽！
有增强免疫的作用,我查了很多资料,没有这东西的结构式,请把结构式上传一下.知道了结构式才能更多的了解其理化性质.
RN = 0
SY = TZ-93
SY = TZ 93
HM = *Triterpenes
SO = Transplant Proc 1996 Jun;28(3):1379-80
FR = 6
NO = a phenolic nortriterpene; isolated from the root cortex of Tripterygium Wilfordii Hook f.
DA = 19960731
MR = 20020107
UI = C099855
Immunosuppressive and Anti-Inflammatory Effects of Phenolic Nortriterpenoid, Demethylzeylasteral, from Tripterygium wilfordii
TOHRU TAMAKI, TAKASHI MOROTA*, HIDEKI KAWAMURA*, HIROFUMI MARUYAMA*, ATSUSHI KANEKO*, SHINYU NUNOME*, YASUHIRO KOMATSU*, WAN-ZHANG QIN**, BING-HUI YANG**, AKIO KAWAMURA
Research Institute for Artificial Organ, Transplantation and Gene Therapy, Sapporo Hokuyu Hospital, *Tsumura Cantral Research Laboratories, **Zhong Shan Hospital of Shanghai Medical University
Natural Medicines, 51(2) : 98-104, 1997.
Original Paper Pharmacology Planta Med 2005; 71: 313-319
DOI: 10.1055/s-2005-864096
Antimicrobial Activity of 6-Oxophenolic Triterpenoids. Mode of Action against Bacillus subtilis
Leandro de Leon1, Beatriz Beltran1, Laila Moujir1
1 Departamento de Microbiologia y Biologia Celular, Facultad de Farmacia, Universidad de La Laguna, Tenerife, Canary Islands, Spain
Abstract
Zeylasteral and demethylzeylasteral are 6-oxophenolic triterpenoids isolated from the root of Maytenus blepharodes, which have antimicrobial activity against Gram-positive bacteria and the yeast Candida albicans. The time-kill curves for zeylasteral and demethylzeylasteral at concentrations twice their MICs, against Bacillus subtilis showed that the colony forming units were reduced in 3-log10 and > 4-log10 respectively. This reduction was dependent on inoculum size and the growth phase of cells, and was greater when the compounds were incorporated in the exponential phase, indicating a bacteriolytic effect. Treatment with both agents, particularly with zeylasteral (20 μg/mL) caused a reduction of optical density at 550 nm. With regard to the synthesis of DNA, RNA, protein and cell wall, the compounds exhibited the fastest inhibition against cell wall synthesis. Thus, the predisposition to lysis, the morphological changes seen by microscopy, and the complete inhibition in the incorporation the N-acetyl-D-glucosamine, suggest that the phenolic compounds compromise the cell wall synthesis and/or cytoplasmic membrane.
Key words
6-Oxophenolic triterpenoids - Maytenus blepharodes - Celastraceae - antibacterial activity - Bacillus subtilis - mode of action - macromolecular synthesis - cell wall
根据其结构式,该化合物极性不大,还有酸性,可以通过萃取和大孔吸附树脂纯化.还可以配合吉拉德试剂纯化.
希望有人指点一二，感激不尽！
有增强免疫的作用,我查了很多资料,没有这东西的结构式,请把结构式上传一下.知道了结构式才能更多的了解其理化性质.
RN = 0
SY = TZ-93
SY = TZ 93
HM = *Triterpenes
SO = Transplant Proc 1996 Jun;28(3):1379-80
FR = 6
NO = a phenolic nortriterpene; isolated from the root cortex of Tripterygium Wilfordii Hook f.
DA = 19960731
MR = 20020107
UI = C099855
Immunosuppressive and Anti-Inflammatory Effects of Phenolic Nortriterpenoid, Demethylzeylasteral, from Tripterygium wilfordii
TOHRU TAMAKI, TAKASHI MOROTA*, HIDEKI KAWAMURA*, HIROFUMI MARUYAMA*, ATSUSHI KANEKO*, SHINYU NUNOME*, YASUHIRO KOMATSU*, WAN-ZHANG QIN**, BING-HUI YANG**, AKIO KAWAMURA
Research Institute for Artificial Organ, Transplantation and Gene Therapy, Sapporo Hokuyu Hospital, *Tsumura Cantral Research Laboratories, **Zhong Shan Hospital of Shanghai Medical University
Natural Medicines, 51(2) : 98-104, 1997.
Original Paper Pharmacology Planta Med 2005; 71: 313-319
DOI: 10.1055/s-2005-864096
Antimicrobial Activity of 6-Oxophenolic Triterpenoids. Mode of Action against Bacillus subtilis
Leandro de Leon1, Beatriz Beltran1, Laila Moujir1
1 Departamento de Microbiologia y Biologia Celular, Facultad de Farmacia, Universidad de La Laguna, Tenerife, Canary Islands, Spain
Abstract
Zeylasteral and demethylzeylasteral are 6-oxophenolic triterpenoids isolated from the root of Maytenus blepharodes, which have antimicrobial activity against Gram-positive bacteria and the yeast Candida albicans. The time-kill curves for zeylasteral and demethylzeylasteral at concentrations twice their MICs, against Bacillus subtilis showed that the colony forming units were reduced in 3-log10 and > 4-log10 respectively. This reduction was dependent on inoculum size and the growth phase of cells, and was greater when the compounds were incorporated in the exponential phase, indicating a bacteriolytic effect. Treatment with both agents, particularly with zeylasteral (20 μg/mL) caused a reduction of optical density at 550 nm. With regard to the synthesis of DNA, RNA, protein and cell wall, the compounds exhibited the fastest inhibition against cell wall synthesis. Thus, the predisposition to lysis, the morphological changes seen by microscopy, and the complete inhibition in the incorporation the N-acetyl-D-glucosamine, suggest that the phenolic compounds compromise the cell wall synthesis and/or cytoplasmic membrane.
Key words
6-Oxophenolic triterpenoids - Maytenus blepharodes - Celastraceae - antibacterial activity - Bacillus subtilis - mode of action - macromolecular synthesis - cell wall
根据其结构式,该化合物极性不大,还有酸性,可以通过萃取和大孔吸附树脂纯化.还可以配合吉拉德试剂纯化.